Effect of oleo-gum-resin of Boswellia serrata (Kundur) on renal functions in Albino rats

Oleo-gum-resin of Boswellia serrata Roxb. (Burseraceae) locally called ‘Kundur’, is one of the ingredients in certain Unani formulations used in renal diseases. In the present study, the effect of Kundur and its methanol soluble (MS), and methanol insoluble (MINS) fractions were investigated on Gentamicin induced nephrotoxicity in Albino rats. The renal effects of Kundur and its fractions were studied by monitoring urea and creatinine blood levels. Aminoglycoside antibiotics including Gentamicin are widely used in the treatment of Gram-negative bacterial infections. A major complication of the use of these drugs is nephrotoxicity. In the current study, treatment with Kundur its methanol soluble (MS) and methanol insoluble (MINS) fractions significantly prevented the rise in blood urea and serum creatinine levels. Our results suggest that Kundur and its (MS) methanol soluble fraction induced renoprotective action against Gentamicin induced nephrotoxicity probably due to the presence of compounds possessing antioxidant potential.